Once you select Custom, the various policies categorized into sections get enabled.
Select Custom, to finetune the policies as per your enterprise requirements. The Custom baseline lets admins define their policies as per requirements. Select any one baseline to see the presets and once you have reviewed them, update profile to enforce these settings on device. Basic, Medium and Advanced have policies pre-configured. There are four baselines provided here, viz Basic, Medium, Advanced and Custom which get enabled after toggling on Configure Defender Policies. This allows you to start configuring various settings and also prompt the end users that they need to configure policies. To configure Defender policies, toggle ON Configure Defender Policies. Once in the Device Profile wizard, click on the Settings > Security Settings > Windows Defender section to configure Defender policies. 
Click on a Windows Device profile and edit, or create a new Windows Device profile.
Navigate to Device Profiles & Policies > Device Profiles. Defender policies work on Windows 10 version 1809 and above, and on Windows Pro, Business, Enterprise, Education editions. The document below describes all Windows Defender policies and how they can be configured. With Windows Defender feature, admins can configure policies ranging from scanning, real-time monitoring, signature updates to certain advanced ones like cloud protection and more, thereby protecting the systems from malware threats. With Scalefusion MDM, administrators can now configure and push various Windows Defender policies on their managed Windows devices. Microsoft's Windows Defender, now known as Microsoft Defender Antivirus provides real-time protection of Windows devices against software threats like viruses, malware, and spyware across email, apps, cloud, and the web.
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